Importantly, exposure to refluxate regardless of acid content can trigger inflammatory responses, with interleukins such as IL-6, IL-8, and IL-1β, playing key roles as mediators of mucosal inflammation, contributing to tissue injury and the progression of GERD to BE and EAC [6,12,13,14,15,16]. This evidence concerns the gene CXCL8 and Barrett esophagus.