In the current study, treatment with 78c enhanced NAD+ (Figure 4F) and subsequently increased Sirt1 mRNA and protein expressions in old murine BMMs either uninfected or infected with oral pathogens (Figure 5I and Figure 6C), supporting that treatment with 78c is a promising therapeutic approach to treat aging-associated periodontitis, which can enhance NAD+ and Sirt1, maintain mitochondrial homeostasis and metabolic function, and promote longevity. The gene discussed is SIRT1; the disease is periodontitis.