Proteins such as APOE, CD14, CNDP1, CTNT1, DKK3, IGHA1, IGHG3, IGKC, NPTXR, PTGDS, and VGF provide valuable insights into the complex and interrelated mechanisms of immune regulation, neurodegeneration, and cellular signalling in MS. Here, PTGDS is linked to myeloid sarcoma.