This study presents a comprehensive meta-analysis of proteomics data from MS patients’ CSF, resulting in the identification of several essential proteins, including APOE, CD14, and PTGDS for neuroinflammation, CNDP1, NPTXR, and VGF for neurodegeneration, CTNT1 and DKK3 for repair mechanisms, and IGHA1, IGHG3, and IGKC as hallmarks of MS. Here, NPTXR is linked to myeloid sarcoma.