IL22 and inflammatory bowel disease: In addition, while basolateral levels of IL-4, IL-9, IL-17A, IL-21, and IL-22 increased upon ConA stimulation of the cells (Table S1), IL-4, IL-9, IL-17, and IL-21 significantly decreased upon treatment of the cells with the luminal samples from the IBD-M-SHIME® inoculated with MH002, when compared to donor-matched vehicle control samples (p = 0.001, p = 0.006, p = 0.0003, and p = 0.01 for IL-4, IL-9, IL-17, and IL-21, respectively; Figure 5B–E).