A recent proteomic study by Grieco et al. (2024) [13] revealed that AD lesional skin displays higher expression of VDR, CYP27B1, CYP24A1, and CAMP compared to perilesional skin, particularly in patients with more severe disease, suggesting an attempt by the skin to counteract inflammation and microbial challenge. This evidence concerns the gene CYP24A1 and Alzheimer disease.