Additionally, VDR expression was lower in patients with comorbid asthma (p = 0.036), and significantly reduced levels of OCLN (p = 0.006), CTNNB1 (p = 0.004), and FLG2 (p = 0.046) were observed in patients with total serum IgE ≥ 100 IU/mL. The gene discussed is IGHE; the disease is asthma.