Moreover, the GPP130/GOLIM4 gene has been implicated in head and neck cancer through a study that identified it as a downstream target of stromal interaction molecule 1 (STIM1), a Ca2+ channel protein involved in store-operated calcium entry (SOCE)—a pathway activated in response to decreased Ca2+ levels in the ER [24]. The gene discussed is STIM1; the disease is head and neck cancer.