Surprisingly, EAI045 completely blocked EGF-mediated phosphorylation of T790M/L848R and T790M/C797S/L858R, but just slightly decreased pAkt levels, suggesting that these two mutants may enhance pAkt independently of the phosphorylation of EGFR at tyrosine 1173, at least in these melanoma cells. The gene discussed is EGFR; the disease is melanoma.