In oestrogen-deficient rats with osteoarthritis induced by monosodium iodoacetate (MIA), MP also preserved joint integrity by modulating the expression of matrix metalloproteinase-13 (MMP-13) and its inhibitor, i.e., Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) [45]. The gene discussed is MMP13; the disease is osteoarthritis.