PGF and preeclampsia: Even 80–90% of women with EO-PE have abnormal maternal plasma soluble Fms-like Tyrosine Kinase-1-to-placental growth factor (sFlt-1:PlGF) or placental growth factor-to-soluble Endoglin (PlGF:sEng) ratios; this imbalance affects only 40–50% of patients with late-onset preeclampsia [9,10].