In individuals with type 1 diabetes who are fasting and do not have the capacity to secrete insulin from their beta cells, the inhibitory impact of GLP-1 on glucagon production has also been observed, suggesting that the glucagonostatic action of GLP-1 may be mediated without the help of endogenous insulin levels [65,66,67]. The gene discussed is GCG; the disease is type 1 diabetes mellitus.