INS and Insulin resistance: Similar to the study conducted by Calanna S. in an adult population, Stinson S. E. et al. evaluated the incretin effect in a cohort of 80 children and adolescents from the Danish Childhood Obesity Data and Biobank—HOLBAEK study (ClinicalTrials.gov identifier number NCT00928473), aged 7 to 17 years, grouped based on BMI and Matsuda index into three categories: obese with insulin resistance, obese with normal insulin sensitivity, and normal-weight controls [73,74].