CD177-positive neutrophils, which are enriched in IBD, produce elevated ROS, antimicrobial peptides (AMPs), and NETs, while displaying a diminished secretion of pro-inflammatory cytokines (IL-6, IL-17A, and IFN-γ) and increased levels of regulatory cytokines (TGF-β and IL-22), facilitating mucosal repair [81,82]. Here, IFNG is linked to inflammatory bowel disease.