Alterations in levels of ceramides in plasma and serum have been found in previous studies including major psychiatric disorders beside BD and SCH such as depression (increased levels of Cer (16:0), Cer (18:0), Cer (20:0), Cer (22:0), Cer (24:0), Cer (24:1), Cer (26:1), hexosylCer, LacCer, and sulfatides), anxiety (increased levels of Cer (16:0), Cer (16:1), Cer (18:1), Cer (23:1), Cer (20:0), Cer (22:1), Cer (24:0), Cer (26:1), and Cer (36:4)), and attention deficit hyperactivity disorder (increased levels of Cer (22:0); decreased levers of Cer (24:0) and Cer (d24:1)) [137]. Here, CBLN1 is linked to spindle cell hemangioma.