T-cadherin is abundantly present in the basal layer of keratinocytes in normal skin and its expression is lost upon malignant transformation as well as in numerous human cancers such as breast and lung carcinomas, cutaneous squamous cell carcinomas, pituitary adenomas, malignant B cell lymphomas and nasopharyngeal carcinoma, osteosarcoma, ovarian cancer and endometrial cancer, and gallbladder cancer [3,18]. Here, CDH13 is linked to cutaneous squamous cell carcinoma.