In the skin, strong T-cadherin expression in the basal layer of keratinocytes is lost upon malignant transformation, paralleling its downregulation observed in many carcinomas (breast, lung, and cutaneous squamous cell carcinomas), pituitary adenomas, B-cell lymphomas, and nasopharyngeal carcinoma [23]. This evidence concerns the gene CDH13 and cutaneous squamous cell carcinoma.