In light of that, the observed alterations induced by TGF-β1 in the U-87MG FIBRO cell line led to a significant increase in TMZ resistance, affecting cytotoxicity, senescence, and apoptosis, aligning with previous observations that fibrotic-like features can enhance tumor cell survival (Figure 2A–C) [44,45,46]. This evidence concerns the gene TGFB1 and neoplasm.