In line with our model, in glioma cells, Wendt et al. found that TGF-β drives mesenchymal traits via FAK/PI3K, but following chronic exposure to TGF-β, FAK may undergo de-phosphorylation or be internalized/degraded, with the loss of anchor signal and the suppression of downstream factors [43]. Here, TGFB1 is linked to glioma.