To further validate the results, the bioactive compounds chlorogenic acid, quinic acid, orientin, homoorientin, vitexin, isovitexin, and naringin-7-rhamnoglucoside were docked with the previously identified melanoma protein targets which were the proto-oncogene serine/threonine protein kinase, a mitogen-activated protein kinase, cyclin-dependent kinase 2, and phosphoinositide-dependent kinase-1. This evidence concerns the gene AKT1 and melanoma.