It was shown that AID is capable of inducing double-stranded genome DNA breaks, leading to chromosomal translocations between IgH genes and oncogenes: c-myc in Burkitt lymphoma [16,17,18], BCL2 and BCL6 in diffuse large B-cell lymphoma [19,20] and CCND1 in mantle cell lymphoma [18]. The gene discussed is AICDA; the disease is diffuse large B-cell lymphoma.