PTP1B (Protein tyrosine phosphatase 1B) inhibitors have been isolated from numerous species of soft corals including gorgonian corals which can be useful to inhibit PTP1B, known as the target enzyme of new therapeutic drugs (and evaluation of marine compounds as potent inhibitors) in the treatment of type 2 diabetes, obesity, and breast cancer [206]. Here, PTPN1 is linked to obesity due to melanocortin 4 receptor deficiency.