The strategic rejuvenation of hippocampal neurogenesis—via synergistic pharmacological modulation (BDNF/TrkB activation), natural product-mediated NSC priming (curcumin/DISS), and lifestyle interventions (exercise; Mediterranean diet)—represents a paradigm shift in AD therapeutics, with the NII framework enabling stage-specific personalized therapy. This evidence concerns the gene BDNF and Alzheimer disease.