APP and Alzheimer disease: Neurogenesis impairment has been observed in APP/PS1 mice at 6 months of age, in 5×Tg-AD (APP KM670/671NL (Swedish), APP I716V, APP V717I, PSEN1 M146L (A>C), PSEN1 L286V) mice before 2 months of age, and in 3×Tg-AD (APP KM670/671NL (Swedish), MAPT P301L, PSEN1 M146V) mice at 4 months of age [28].