COVID-19 severity is linked to elevated levels of inflammatory mediators, including cytokines (e.g., IL-2, IL-7, IL-10, IFN-γ, and TNF-α) and chemokines (e.g., G-CSF, MCP1, MIP1α, and CXCL10), as well as markers like C-reactive protein, ferritin, and D-dimers [22,23,24,25,26]. The gene discussed is TNF; the disease is COVID-19.