Of interest, Faecalibacterium, known to exert anti-inflammatory actions through the production of butyrate [186], was also depleted in patients with autoimmune diseases (multiple sclerosis, Sjögren’s syndrome, systemic lupus erythematosus) [187] and positively associated with both anti-Dsg1 and anti-Dsg3 antibody titers in patients with active pemphigus [17]. This evidence concerns the gene DSG3 and autoimmune disease.