Furthermore, consistent with Guo et al. [173], Enterobacter spp., which behaves as both facultative anaerobic Gram-negative natural commensals and opportunistic pathogens (behavior observed for Enterobacter aerogenes, Enterobacter cloacae, and Enterobacter hormaechei), were positively associated with Dsg3 autoantibodies, thus representing potential inducers of PV [148]. This evidence concerns the gene DSG3 and acquired polycythemia vera.