CACNA1A and epilepsy: We observed the upregulation of genes such as cacna1aa, cacna1c, cacna1da encoding the calcium channel subunits Cav2.1, Cav1.2, and Cav1.3, whose GOF mutations in humans lead to excessive Ca2+ entry and increased neuron excitability causing developmental disorders such as epilepsy or ASD [100,101,102].