Furthermore, we have also observed the upregulation of voltage-gated sodium channel genes such as kcna1a, kcnq3, kcnb1, kcnc1b, and kcnd1 whose orthologs in humans have been implicated in epilepsy syndromes like DEE by either LOF or GOF mutations [110,111,112,113,114,115]. Here, KCNQ3 is linked to epilepsy syndrome.