TGFB1 and fibrosis: Fibrosis-related lncRNAs: Furthermore, the overexpression of 3110045C21Rik promotes the up-regulation of E-cadherin (Cdh1) while suppressing the expression of alpha-smooth muscle actin (Acta2) and Transforming Growth Factor Beta 1 (Tgfb1), key markers associated with the development and progression of fibrosis [24].