Molecular docking revealed information about the precise interactions between 3-HBI and proteins in the SMAD2/3 pathway, as there are several proteins that bind in the SMAD signaling pathway This implies that 3-HBI prevents HSC activation by interfering with the TGF-β/SMAD signaling pathway, which might reduce liver fibrosis. This evidence concerns the gene TGFB1 and Hepatic fibrosis.