DNA methylation patterns involving genes like CCNA1, C13ORF18, DAPK, HIC-1, HIN-1, MGMT, RAR-beta, and RASSF1A were also modeled as influential epigenetic factors affecting different transition states from normal tissue to invasive carcinoma [19,20,21,31]. This evidence concerns the gene DAPK1 and invasive carcinoma.