We have also found that LCS1269 triggered G2 cell cycle block associated with Wee1/Myt1 axis activation, the upregulation of transcription factor Forkhead Box M1 (FOXM1), and its target Polo Like Kinase 1 (PLK1) in human glioblastoma cell lines [20]. The gene discussed is MYT1; the disease is glioblastoma.