Other assays such as SelectMDx and ConfirmMDx detect DNA hypermethylation patterns in tumor suppressor genes (e.g., GSTP1, RASSF1), which are influenced by the availability of metabolic cofactors like S-adenosylmethionine (SAM) and acetyl-CoA—central intermediates in epigenetic regulation. This evidence concerns the gene RASSF1 and neoplasm.