The subsequent low glucose intake, and disrupted glycolysis in PCa cells by β-elemene followed multi-target affectations in glutamine metabolism-related enzymes such as glutamine dehydrogenase 1 (GLUD1) and GLS, or glucose-6-phosphate dehydrogenase (G6PD), which is a pivotal for pentose phosphate pathway (PPP) regulation. Here, G6PD is linked to posterior cortical atrophy.