The diminished levels of free fatty acids in PCa cells correlated with low acetyl CoA levels and the induced apoptosis by Withaferin A treatment, suggesting a role of MYC in the inhibition of fatty acid synthesis, which was confirmed by the low expression of other enzymes of de novo lipid synthesis in vivo, such as ACC1 and FASN. The gene discussed is MYC; the disease is posterior cortical atrophy.