The relationship between these enzymes and metabolic regulators is determined by AR, generating a hybrid phenotype of glycolysis/OXPHOS in PCa through multiple means, inducing glycolysis, either by the activation of PFKFB2 and HK2, or the transport of pyruvate to the mitochondria mediated by dynamin-related protein 1 (DRP1) or of OXPHOS via the AMPK-peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) signaling cascade [16,31]. The gene discussed is HK2; the disease is posterior cortical atrophy.