LDHA and posterior cortical atrophy: Through the highly expressed glycoprotein stanniocalcin 1 (STC1) in advanced PCa independent of androgens, an Nrf2-inducing mechanism is achieved that increases glycolysis, enhancing the expression of enzymes such as HK2 and LDHA, as well as other Nrf2 downstream targets, including GPX4, the glutamine transporter SLC7A11, and NQO1 and HO-1 products [153].