A comprehensive transcriptomic analysis based on RNA sequencing (RNA-seq) conducted by Silva et al. [17] identified differential expression of three key genes associated with RvD2 biosynthesis and signaling—PLA2G7, ALOX5AP, and GPR18—in the intestinal mucosa of CD patients compared to non-inflammatory bowel disease (IBD) controls. This evidence concerns the gene GPR18 and inflammatory bowel disease.