As for the study of TIM-3 in gynecologic cancers, it showed that PD-L1 and TIM-3 are prognostically significant biomarkers of active and suppressed immune responses against high-grade serous ovarian cancer, and this study demonstrated that TIM-3 dictates the functional orientation of immune infiltration in ovarian cancer [17]. This evidence concerns the gene HAVCR2 and female reproductive organ cancer.