Using a retrospective cohort of 80 chemotherapy-naive HGSC patients, Fucikova et al. investigated the relationship between prognosis and the functional orientation of the tumor microenvironment, including PD-L1 expression and infiltration by CD8+ T cells, CD20+ B cells, DC-LAMP+ dendritic cells, as well as PD-1+, CTLA-4+, LAG-3+, and TIM-3+ cells. This evidence concerns the gene LAG3 and neoplasm.