In various studies on HSC, it has been shown that different concentrations of HE suppressed the expression of Alpha-Smooth Muscle Actin (α-SMA) and Collagen Type 1 Alpha 1 Chain (COL1A1), thereby preventing the progression of liver fibrosis and the deposition of Extracellular Matrix (ECM) elements [26,27]. Here, ACTA1 is linked to hereditary elliptocytosis.