HE also enhanced fatty acid oxidation by increasing SIRT1 (0.73 ± 0.16 vs. 2.36 ± 0.10 at 50 μg/mL) and PGC1α (0.71 ± 0.03 vs. 0.89 ± 0.003 at 50 μg/mL). The gene discussed is PPARGC1A; the disease is hereditary elliptocytosis.