NOS2 and breast cancer: The ferroptosis of BC cells induces the increased expression of M1 markers (such as CD86 and iNOS), the secretion of proinflammatory cytokines (such as TNF-α and IL-12), and the decreased expression of M2 markers (such as CD206 and ARG-1) in TAMs, thereby promoting M1-type macrophage polarization and inhibiting tumor growth.