NFKB1 and breast cancer: Li et al. constructed a 4T1-Luc metastasis-tracking model of orthotropic BC and demonstrated that M2 TAM-mediated CXCL1 transcriptionally activates the NF-κB/forkhead box protein P3 signaling pathway to promote CD4+ T cell differentiation into Treg, followed by immune escape and lung metastasis [195].