Elder et al. demonstrated that SEMA7A overexpression in involutional breast epithelial cells stimulated the expression of myeloid-derived podoplanin (PDPN) on M2 TAMs, leading to the adhesion of PDPN-expressing M2 TAMs to lymphatic endothelial cells, lymphatic remodeling, and BC metastasis [138]. The gene discussed is PDPN; the disease is breast cancer.