Kumari et al. synthesized self-assembled amphiphilic PEGylated galactomannan (GM) nanoparticles loaded with HC (PSGM-HCNPs), and the results revealed that PSGM-HCNPs repolarized IL-4-stimulated RAW 264.7 cells by increasing ROS levels, decreasing CD206 and ARG-1 expression, and promoting proinflammatory cytokine secretion, thus reducing the tumor burden and prolonging the survival time of Ehrlich’s ascites carcinoma-bearing mice [238]. The gene discussed is MRC1; the disease is neoplasm.