Whereas, in a sample of older patients undergoing laparoscopic hepatobiliary surgery, peripheral inflammatory markers were associated with perioperative sleep disturbances, but varied between pre-surgery (neutrophil-to-lymphocyte ratio, systemic Immune-inflammation index, IL-6, IL-10) and post-surgery (neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, IL-10) sleep disturbances [7]. This evidence concerns the gene IL6 and Sleep disturbance.