Among the various inflammasomes identified to date, the nucleotide-binding domain, leucine-rich repeat-containing receptor pyrin domain containing three (NLRP3) inflammasomes has gained particular attention due to its involvement in numerous cardiovascular conditions, including AF, heart failure, and post-infarction remodeling [10,11,12,13,14,15,16]. The gene discussed is NLRP3; the disease is heart failure.