S100B and myeloid sarcoma: A significant reduction of astrocytosis, demyelination, immune infiltrates, and proinflammatory cytokine expression was observed when the expression of the S100B protein was impaired, indicating the participation of S100B in neuroinflammatory processes [30,32], reasonably as an astrocytic activity, since astrocytes are known to express and release S100B and are also regarded to be directly involved in MS processes [9,10,33].