While nuclear TEAD4 has previously been linked to prognosis in other malignancies, such as bladder cancer [44,45], renal clear cell carcinoma [46], and lung adenocarcinoma [47], and one glioma study applied a combined nuclear–cytoplasmic score [48], cytoplasmic TEAD4 has not previously been evaluated as an isolated prognostic variable. Here, TEAD4 is linked to central nervous system cancer.