In all but one of the B3/TC cases (96.4%) we observed an expression of SAV1 in all tumor cells, whereas in 24.5% of the rest WHO histological types there were also negative tumor cells within the tumor area (Fisher’s exact test, p = 0.025).The same applied to cases with advanced Masaoka-Koga stage, which all displayed a positive expression of SAV1 in all tumor cells, whereas in 23.4% of the stage I/II cases we found also negative tumor cells within the tumor (Fisher’s exact test, I/II versus III/IV, p = 0.027). The gene discussed is SAV1; the disease is neoplasm.