Xu et al. demonstrated that APS (200–400 mg/L) significantly inhibited the invasion (by 19–47%) and metastasis (by 30–43%) of liver cancer SMMC-7721 cells, primarily by downregulating the JAK/STAT signalling pathway, as indicated by reduced p-STAT3/STAT3 and p-STAT5/STAT5 ratios. The gene discussed is STAT3; the disease is liver cancer.