Recent studies have shown that circRNAs derived from the Plasmacytoma Variant Translocation 1 (PVT1) gene (circPVT1) regulate 5-fluorouracil (5-FU) chemosensitivity in esophageal squamous cell carcinoma (ESCC) by modulating the Wnt/β-catenin pathway through the miR-30a-5p/FZD3 axis [39]. This evidence concerns the gene FZD3 and esophageal squamous cell carcinoma.