According to current evidence, albumin supplementation should be employed only in specific scenarios [6,18], such as spontaneous bacterial peritonitis, hepatorenal syndrome, large-volume paracentesis, uncomplicated grade 2 and 3 ascites, severe acute pancreatitis, and Coronavirus Disease 2019 (COVID-19) infection [5,21,22,23,24,25]. This evidence concerns the gene ALB and COVID-19.