Additional pharmacological treatments include mast cell stabilizers, corticosteroids for more severe or widespread reactions, nonsteroidal anti-inflammatory drugs (NSAIDs) to alleviate conjunctival injection and itching, leukotriene inhibitors for mild persistent asthma, seasonal allergic rhinitis, and urticaria, and anti-IgE antibodies and immunotherapy in selected cases. This evidence concerns the gene IGHE and allergic rhinitis.