Clonal hematopoiesis not only raises the risk of cancer and mortality but also increases the likelihood of cardiovascular disease, particularly due to mutations in genes such as ten-eleven translocation 2 (TET2), DNA methyltransferase 3 alpha (DNMT3A), ASXL transcriptional regulator 1 (ASXL1), and Janus kinase 2 (JAK2). This evidence concerns the gene DNMT3A and cancer.