Loss-of-function gene mutations encoding heat shock protein-β1 (HSPB1, UniProt ID: P04792) cause human lamellar cataracts, and its levels increase in lens tissue cultures upon exposure to high-dose glucocorticoids that bind to nucleophilic amino acids and destabilize proteins, which is responsible for posterior subcapsular cataract development after steroid treatment [50]. This evidence concerns the gene HSPB1 and cataract 5 multiple types.