Growth differentiation factor 15 (GDF15), Galectin-3, and soluble suppression of tumorigenicity 2 (sST2) have emerged as potential novel HF-related biomarkers, given their roles in fibrosis, myocardial stress, pro-oxidant conditions, and systemic inflammation [26,27,28]. The gene discussed is LGALS3; the disease is hydrops fetalis.