TET2 and metabolic dysfunction-associated steatotic liver disease: CHIP was shown to be associated with an increased risk of MASLD via accelerated inflammatory responses by Wong and colleagues who conducted a combination of large-scale human genetic studies and an animal study using hematopoietic-specific Tet2-deficient mice as a clonal hematopoiesis model manifesting severe steatohepatitis with increased liver inflammation and fibrosis [35].