Among patients with AF-related stroke, the predictors of severe stroke (NIHSS ≥ 15) included high ATRIA score (OR = 1.712, 95% CI: 1.348–2.173, p < 0.001), reduced EF (OR = 0.957, 95% CI: 0.918–0.999, p = 0.044), and elevated CRP levels (OR = 1.022, 95% CI: 1.007–1.037, p = 0.004). The gene discussed is CRP; the disease is Stroke.