Furthermore, the cut-off expression levels of NFE2L2 > 1.34-fold, NFKB1 > 0.78-fold and SIRT1 < 0.88-fold predicted an increased risk of CIN by 26.32 (95% Cl: 3.731–166.667; p < 0.001), 11.5 (95% Cl: 3.043–43.461; p < 0.001) and 2.36 (95% Cl: 1.216–4.587; p = 0.004) times, respectively. Here, SIRT1 is linked to cervical squamous intraepithelial neoplasia.