According to ROC analysis, with respect to increasing the risk of developing CIN, we found that 96% sensitivity and 100% specificity for NFE2L2 with 1.34- (AUC: 0.977; 95% CI: 0.987–1; p < 0.001), 100% sensitivity and 96% specificity for NFKB1 with 0.78-fold (AUC: 0.998; 95% CI: 0.993–1; p < 0.001), 100% sensitivity and 100% specificity for FOXO1 with 1.32-fold (AUC: 1.000; 95% CI: 1–1; p < 0.001). This evidence concerns the gene NFKB1 and cervical squamous intraepithelial neoplasia.