MPO and interstitial lung disease: Similarly, in a large retrospective cohort (n = 684), 13% of the patients had ILD (93% MPO-ANCA-positive), and mortality was higher in the ILD group (38% vs. 25%; p = 0.005), with a 39% increased risk of death after adjusting for age and sex, and 58% when all fibrotic patterns were included.