In contrast, a large Mayo Clinic study (1862 patients with AAV, 143 with ILD) indicated better survival in patients with MPO-ANCA with a UIP pattern than in those with other ILD patterns, suggesting differences in the mechanisms underlying the development of ILD in MPO-AAV versus PR3-AAV [72]. The gene discussed is PRTN3; the disease is idiopathic pulmonary fibrosis.