Given aldosterone’s role in cerebrovascular remodelling, promotion of vascular inflammation and oxidative stress, and disruption of cerebral blood flow regulation, as well as the presence of MR in the hippocampus, a region critical for cognitive function, we conducted a study on cognitive function in 15 targeted treatment naive individuals with PA and arterial hypertension, and 15 age and sex-matched controls with EH, all free of previous cerebrovascular events. Here, NR3C2 is linked to Hypertension.