Neuroanatomically, the tau pathology characteristic of early Alzheimer’s disease may disrupt vestibular–cognitive pathways by impairing synaptic function in the hippocampus, entorhinal cortex, and retrosplenial cortex—regions that receive vestibular input via multisynaptic projections from the vestibular nuclei through the thalamus [36]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.