IL10 and arthritic joint disease: In the study herein, we have further examined in the K/BxN arthritis model, the effect of rFc-μTP-L309C on the expression of T-cell subsets, including Th1, Th17 and T-regulatory cells (Tregs) in the spleens, lymph nodes and joints, as well as production of anti-inflammatory molecules, IL-10 and TGF-β, in the joint synovial fluid.