In various metabolic diseases, alterations are observed in several myokines, such as interleukin-6 (IL-6), interleukin-15 (IL-15), metronin-like (Metrnl), irisin and leukemia inhibitory factor (LIF), whose levels and functions are modified, affecting energy metabolism, inflammation and interorgan communication. This evidence concerns the gene FNDC5 and metabolic disease.