ENG and vascular malformation: Initial investigations into the etiology of HHT-associated vascular malformations focused on the expression of endoglin (encoded by ENG) and ALK1 (the commonly used term for the protein encoded by ACVRL1) in monocytes and neonatal human umbilical vein endothelial cells (HUVECs) from affected individuals [16,17,18,19,20].